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Og mens flere legemidler kan alene være svært gode, kan de dersom de brukes samtidig som et annet legemiddel i verste drop bli en dødelig «cocktail».Økt opplevelse av kontroll og trygghet kan fileøre til mindre smerte og ubehag. Et rolig nervesystem demper smerte, mens uro kan forsterke det. Omvendt kan engstelse og opplevelse av ikke å ha